Can CBD Gummies Upset Your Stomach?

Can CBD Gummies Upset Your Stomach?

So, one of the reasons why many people are incorporating natural solutions into their treatment regimens is to avoid the side effects associated with the long-term use of some conventional medicines. Natural fixes are considered less toxic, even if their effectiveness remains debatable.

For example, common over-the-counter medicines such as non-steroidal anti-inflammatory drugs (NSAIDs) are not recommended for long-term use. So, if you are dealing with chronic pain due to a condition like arthritis or fibromyalgia that require using painkillers long-term, your doctor would mostly recommend other painkillers. 

That's because NSAIDs can cause bleeding problems and stomach ulcers when used for long. Principally, it is because they affect the production of prostaglandins which are vital for critical functions like blood clotting. Besides, these drugs are known to cause adverse reactions like allergies in some people. 

The emergence of cannabidiol (CBD) as a potential remedy for many health problems is based on years of cannabis use going back to ancient times. Since the 1950s, scientists have uncovered many of this cannabinoid's health benefits. But what about its downsides? 

Key takeaways 

  • CBD is a non-psychoactive cannabinoid found in cannabis (hemp).
  • It affects the body by interacting with the endocannabinoid system and other receptors outside the ECS.
  • CBD is generally well-tolerated with rare minimal side effects. Issues like stomach upsets may be due to other factors, e.g., purity of the carrier oil or overuse.
  • Animal studies have noted significant health complications, but these have not been replicated in human models.

What are CBD gummies 

The expanding research on cannabis has yielded valuable insights regarding its potential therapeutic value. Also, we now have a pretty good idea of how CBD, in particular, and cannabinoids, in general, work in the body.

As a result, CBD has become one of the most sought-after cannabis compounds presently. After its extraction from hemp, it can be infused into many different products. CBD gummies rank highly as some of the most popular CBD products around. In fact, a recent Forbes survey indicated that, together with other edibles, they are "the most popular way to consume CBD in the US."

But what are they? CBD gummies are your typically sweet, chewy candies with a slight variation – they have CBD. Ideally, the CBD is mixed with oil before being infused into the gummies.


How CBD affects the body 

Cannabinoids affect the body by interacting with the endocannabinoid system (ECS). This is a network of endocannabinoids (neurotransmitters), enzymes, and receptors that work to ensure body balance, i.e., homeostasis. 

Many things affect body balance, e.g., stress, diseases, environmental factors, changing physiological processes, etc. Without the ECS, our bodies would probably not recover from such changes. So, the ECS plays a crucial role in keeping us healthy.

So, the process of maintaining homeostasis looks like this. When there is an imbalance somewhere in the body, the ECS releases endocannabinoids to check out the problem. Once the endocannabinoids identify the problem, they team up with identical receptors to trigger wide-ranging internal processes to correct the situation. 

Once the problem has been sorted, the ECS sends enzymes to stop further interaction between the endocannabinoids and receptors. The enzymes break down the endocannabinoids, halting the process or processes they were facilitating. Simple, right?

There are two ways to stimulate the ECS. You can engage in natural physical activities, e.g., exercises, yoga, or meditation, or consume phytocannabinoids. 

Cannabis is one of the most cannabinoid-rich plants you can find. Others are black pepper, ginseng, cloves, broccoli, Echinacea, cacao, black truffles, electric daisy, and carrots.

The two most common phytocannabinoids in cannabis are tetrahydrocannabinol (THC) and cannabidiol (CBD). Research shows that these cannabinoids (and many others) have near-identical chemical structures as endocannabinoids. As a result, they have the same effect on the ECS as endocannabinoids. In other words, what endocannabinoids can do, phytocannabinoids can do.

THC binds to both CB receptors, i.e., CB1 and CB2, while CBD demonstrates a low affinity for CB receptors. So, it interacts with other receptors such as ion channels (e.g., TRPV1), opioid receptors, serotonin receptors, and peroxisome proliferator-activated receptors (PPARs). 

CBD's effect on CB1 receptors is mainly antagonistic. It, however, displays partial agonistic properties at CB2 receptors, which explains its ability to influence the immune system. Moreover, CBD's numerous pharmacological sites explain its role in various ECS-mediated physiological processes such as sleep, pain regulation, stress, muscle formation, learning and memory, metabolism, digestion, and inflammation. 

Can CBD gummies make your stomach upset 

most people tolerate CBD quite well. In fact, the World Health Organization (WHO) describes CBD as having minimal abuse potential and low toxicity. Studies also highlight CBD's "favorable safety profile in humans," noting that it has a "better side effect profile" than most drugs.

However, everyone is different, and some people react adversely to CBD. The most commonly observed side effects are fatigue/tiredness, diarrhea, appetite changes, dry mouth, and dizziness.

Furthermore, a 2019 animal study showed that, in higher doses, CBD might cause:

  • Developmental toxicity
  • Hepatocellular injuries
  • Spermatogenesis
  • Hypotension
  • Central nervous system neurotoxicity and inhibition
  • Alterations in the male reproductive system
  • Embryo-fetal mortality
  • Changes in organ weight

When taken orally, CBD can bind to receptors in the digestive system and potentially cause diarrhea. This is more likely if you take it in larger than usual doses. Research suggests CBD is well-tolerated by humans up to doses of 2,000 milligrams per day.

Nonetheless, there is a chance that CBD gummies can cause stomach upset, not least because people respond to CBD differently. 

Does CBD cause diarrhea 

Ideally, no, but there is a chance CBD may also cause diarrhea. This is more likely if ingested in large quantities. This is why it is crucial to stick to the dosing guidelines prescribed on the labels. 

Meanwhile, it also helps to ascertain that there are no ingredients in your diet that you are allergic to. 

Does CBD oil cause diarrhea 

There is no evidence suggesting that CBD oil can cause diarrhea. At best, CBD's side effects are mostly mild and infrequent. When you experience diarrhea after taking CBD, it is most likely that your digestive system is responding to a 'foreign' product in the CBD.

In most cases, diarrhea tends to go away if you continue taking CBD oil. If it does not, you should consider lowering your current dose. If you experience a laxative effect, it is more likely due to the additives or the dilution oil and less likely the CBD. Remember that oil can act as a laxative.

Also, keep in mind that the FDA does not regulate the CBD industry and so manufacturers are at liberty to do as they want with their products. So, you cannot entirely rule out the issue of contamination, which is why you must be keen on where you get your CBD.

Do CBD gummies cause diarrhea 

it is rare to get diarrhea from taking CBD gummies. If the CBD is pure, such cases do not typically arise. CBD gummies are usually made with CBD extract mixed with hemp oil and possibly some flavoring like cinnamon or peppermint. So, unless you have a health issue potentially triggered by the additives, you should generally be okay.

CBD gut motility 

Cannabis research has focused chiefly on CBD's interaction with the endocannabinoid system. In particular, CBD's role in modulating pain, inflammation, mood, mental health problems, and sleep via CB receptors has received significant attention.

Another area where the results have been promising is the effects of CBD on the gastrointestinal (GI) tract and its ability to manage GI problems.

In an animal study, the endocannabinoid receptors CB1 and CB2 were notably increased in the colon tissues of rats with colitis, suggesting the possible involvement of the ECS in GI inflammation. Other studies have shown a relationship between higher cannabinoid levels, activated CB receptors, and improved gastrointestinal inflammation.

Although CBD has a low affinity for CB receptors, it can modulate activity at the CB2 receptors and impact immune system responses.

Not only can CBD directly regulate the ECS, studies show it can alter the concentrations of endogenous cannabinoids (endocannabinoids) by inhibiting their breakdown by the fatty acid amide hydrolase (FAAH) enzyme. The FAAH degrades arachidonoylethanolamine (AEA), commonly known as anandamide.

So, there is little doubt that cannabinoids can affect gut motility, transit time, gastric emptying, and peristalsis. Moreover, hemp CBD has demonstrated the ability to exert anti-nausea and anti-emetic effects and reduce hypermotility in animal models by interacting with 5-HT1A receptors.

Other studies suggest that CBD may help alleviate GI inflammation and protect the intestinal lining by activating the GPR55 receptors. Another study investigating the effects of CBD on human test subjects with ulcerative colitis found that it neutralized reactive enteric gliosis by suppressing the production of macrophages and mast cells in the intestines. It also reduced the expression of TNF-α. 

Consequently, there are suggestions that CBD could be a potential remedy for irritable bowel diseases.

How to avoid stomach pain 

CBD may help you avoid stomach pain. Whether in oil, edibles, or aerosol forms, this cannabinoid demonstrates potent anti-inflammatory and analgesic properties to calm a turbulent stomach and reduce pain.

Oral CBD is considered better suited to handle stomach pain because it is ingested into the stomach. 

What forms of CBD are available 

CBD is a highly versatile compound that can be made into practically anything consumable. At the moment, CBD exists in the form of:

  • Edibles, e.g., gummies and capsules.
  • Topicals, e.g., lotions, creams, and balms
  • Aerosols, e.g., vape cartridges and nasal sprays
  • Oils and tinctures
  • Transdermal patches

How to take CBD gummies 

if you want to boost your health with CBD gummies, here is some vital information. CBD gummies fall in the category of oral CBD, meaning they are ingested and absorbed via the digestive system.

The downside of this method of administration is that the effects typically delay kicking in because the digestive system does not work that fast. Moreover, due to the first-pass mechanism, the bioavailability of oral CBD is quite low. So, you may need to take CBD for longer before it builds up enough in your system to induce benefits.

Our delta-9-THC Chill Gummies are a great way to elevate your mood. They come in two varieties – grapefruit and mojito – infused with additional cannabinoids like CBD, CBD, CBG, and CBDV, and terpenes for a true-to-character cannabis experience. After a tiring workday, these gummies help you relax while inducing a euphoric buzz to help you start your night right.

We also have Sleep Gummies specifically formulated to help you fall and stay asleep. Made with premium-grade CBD, each gummy has 20 mg of CBD and 5 mg of CBN, enough to calm the mind, relax the body, and gently usher you into dreamland!

If you want to unleash the dragon, our Energy Gummies are just about the right way to go about it! These come packed with active cannabinoids like THCV and CBC to rev up your energy reserve and get you going. These are ideal for daytime use.

Some tasks require more focus. No worries, these Focus Gummies improve your focus levels and allow you to concentrate on what matters to you. They are made with THCV and Lion's Mane – ingredients are known for their positive effect on cognitive functioning and an energetic sense of euphoria!

Saving the best for last! These Love Gummies are sure to get your heart pumping and blood flowing to increase energy, libido, and endurance. These all-natural performance-enhancing edibles contain Maca root (a natural aphrodisiac) and CBD to ensure you're GOOD IN BED again!

Where to buy CBD and CBC gummies online 

Interested in the various health benefits of CBD and other cannabinoids? Then don't hesitate to check us out online at Dragon Hemp. All our products are expert-formulated to perform specific functions in your body. We adhere to the highest manufacturing standards and subject our products to independent third-party testing to prove nothing is compromised.

So, click on this link to check out our full range of cannabinoid products. Also, check out some recent research findings on the ability of cannabinoids to reduce the symptoms of inflammatory bowel disease (IBD) in this video.
Back to blog